Background: Patients with chronic kidney disease have a markedly increased cardiovascular mortality compared\nwith the general population. Long chain n-3 polyunsaturated fatty acids have been suggested to possess cardioprotective\nproperties. This cross-sectional and comparative study evaluated correlations between hemodynamic measurements,\nresistance artery function and fish consumption to the content of long chain n-3 polyunsaturated fatty acids in adipose\ntissue, a long-term marker of seafood intake.\nMethods: Seventeen patients with chronic kidney disease stage 5 + 5d and 27 healthy kidney donors were evaluated\nwith hemodynamic measurements before surgery; from these subjects, 11 patients and 11 healthy subjects had\nvasodilator properties of subcutaneous resistance arteries examined. The measurements were correlated to\nadipose tissue n-3 polyunsaturated fatty acids. Information on fish intake was obtained from a dietary questionnaire\nand compared with adipose tissue n-3 polyunsaturated fatty acids.\nResults: Fish intake and the content of n-3 polyunsaturated fatty acids in adipose tissue did not differ between\npatients and controls. n-3 polyunsaturated fatty acid levels in adipose tissue were positively correlated to systemic\nvascular resistance index; (r = 0.44; p = 0.07 and r = 0.62; p < 0.05, chronic kidney disease and healthy subjects\nrespectively) and negatively correlated to cardiac output index (r = âË?â??0.69; p < 0.01 and r = âË?â??0.50; p < 0.05, chronic\nkidney disease and healthy subjects respectively). No correlation was observed between n-3 polyunsaturated fatty\nacid levels in adipose tissue and vasodilator properties in resistance arteries. n-3 PUFA content in adipose tissue\nincreased with increasing self-reported fish intake.\nConclusions: The correlations found, suggest a role for n-3 polyunsaturated fatty acids in hemodynamic\nproperties. However, this is apparently not due to changes in intrinsic properties of the resistance arteries\nas no correlation was found to n-3 polyunsaturated fatty acids.
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